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In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

In an online survey of 153 adults with obesity, most of whom were white and women, those who took semaglutide or tirzepatide reported drinking significantly less than peers not on the medications

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