Net pricing, after rebates and patient assistance, runs materially lower, but the gross-to-net spread in PAH drugs has historically been narrower than in oncology because the payer base is concentrated in private commercial insurance and Medicare Part B, where the rebate dynamics are structurally different from Part D
Rybelsus must be taken on an empty stomach first thing in the morning with no more than four ounces of water
Periods of reduced physical activity due to fatigue or restrictive diets during rapid weight loss can lead to prolonged immobility, increasing the risk of venous stasis and clot formation
Tirzepatide is being used off-label for weight loss in individuals who meet specific criteria
The June 29, 2026 comment deadline falls within days of this article's publication
"We can't say that GLP-1s are actually causing these symptoms," says Neil Sehgal, the study's first author and a doctoral student in CIS advised by Guntuku and Ungar