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Anecdotal evidence suggests it may help with skin lightening, though scientific data remains limited

1 Introduction Aging has always been one of the significant concerns for humans

According to a double-blind placebo-controlled clinical trial by the National Institute of Health [1], Glutathione treatment has proven to significantly lower the skin melanin index of study participants, after a few weeks of use

Luciferase reporter assay HEK293 cells were transiently transfected with indicated plasmids using Lipofectamine 3000 according to the manufacturers instructions

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-sensitive transcription factor that plays a critical role in cellular survival and oxygen homeostasis under hypoxic conditions