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This analysis included 116 participants who had experienced at least one component of the MACE-4 composite endpoint

In addition, GAMT deficiency requires arginine restriction through a low-protein diet, and ornithine supplementation and benzoate (reduces glycine levels via the formation and excretion of hippuric acid) to reduce guanidinoacetate synthesis and its associated toxicity (creatine supplementation also partially inhibits guanidinoacetate formation 4,5 )

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Urology 2009