Patients typically benefit from a slower ramp-upbeginning with lower starting doses and extending the interval between dose increases to allow the gut to adapt
Moreover, IGF-1 levels apparently increased from an average of 100mcg/l at baseline to a plateau value of around 180mcg/l
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Rheumatology 56 , 516523 (2017)
Of note, all the studies undertaken in the OCC included in this meta-analysis used 3 T MRS strength, whereas there was variation in MRS strength across the other brain regions (7 T was used for two MFC studies, with 3 T used for three MFC studies)