The relevance to humans is unknown
Twelve (12) patients were enrolled (3 patients with POMC deficiency, 4 patients with LEPR deficiency, and 5 patients with BBS)
Furthermore, non-users of GLP-1RAs exhibited more than a twofold higher risk of all-cause mortality compared with GLP-1RA users ( 5.1 Systemic and hepatic efficacy: Correcting metabolic derangements and steatosis As depicted in Figure 1, GLP-1 RAs are highly effective at correcting the core metabolic derangements seen in MASLD/T2DM
The combination was well tolerated but an additional arm of the study that involve triple therapy (garetosmab (anti-activin A) was generally not
Figure 4 Graves dermopathy is an extra-thyroidal manifestation exclusively found in GD patients
I was admittedly hesitant to test this out, given the added Biotin and how it causes me to break out, but there was an instant difference in my body a week into adding this gel into my morning routine