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some study reported that L-carnitine supplementation may affect insulin receptors and increase their sensitivity ( Also, oxidative stress causes a disturbance in the function of pancreatic beta cells, and L-carnitine can improve the function of these cells and increase their efficiency by reducing the level of oxidative stress (99), and increased circulating levels of this metabolite can increase the prevalence of diabetes (54% per 5 mol/L increment of plasma TMAO) (100), nonetheless one study showed that increased TMAO plasma level by 30 mol/L after 24 weeks of L-carnitine supplementation was not related to glucose, insulin and HOMA-IR levels changes ( In the subgroup analysis, our results revealed that baseline FBG, trial duration, intervention dose, BMI, and health status had a significant effect on L-carnitine effects on FBG levels

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