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Kant P, Hull MA

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MANF offers neuroprotection by inhibiting NF-B during ER stress and activating the AKT/GSK3-Nrf2 axis, reducing TNF- and IL-6 and slowing neurodegeneration [257]

Most patients return to normal activity quickly while results continue to develop

The bioactivities of this compound include analgesic (pain-relieving) effects, anti-arthritic (anti-inflammatory) effects against joint inflammation (anti-arthritic) effect, antibacterial effect, anti-inflammatory effect, antifungal effect, anticancer effect, antioxidant effect by neutralizing free radicals that damage cells (antioxidant) effect, stomach-protective (gastroprotective) effect, liver-protective (hepatoprotective) effect, heart-protective (cardioprotective) effect, kidney-protective (nephroprotective) effect, and nerve-protective (neuroprotective) effect

For meat-eaters who have a lot of gut bacteria to turn it into TMAO, that could be dangerous, though the safety of this hasn't been studied