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Without structured resistance training, increased protein intake, and body composition monitoring, patients may lose not just fat but vital skeletal muscle and bone, undermining long-term health outcomes

Primary care physicians are mainly concerned about overprescribing or clinically inappropriate prescribing, cited by 56% of doctors, and continuity of care such as follow-up visits, titration, and/or tapering off the medication, cited by half of physicians

Trends Immunol 43(9):757775

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Combination therapies Besides the combination therapies described above, in patients with bridging fibrosis and cirrhosis, combining cilofexor (ACC inhibitor) and firsocostat (FXR agonist) for 48 weeks was well tolerated, showed beneficial effects on MASH disease parameters, and might improve fibrosis