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Despite its advantages, its important to acknowledge GHK-Cus limitations when compared to traditional acne treatments in a research context: Limited Direct Evidence for Active Acne Vulgaris: While it has anti-inflammatory properties, there is currently limited direct clinical evidence specifically demonstrating GHK-Cu as a primary treatment for active acne breakouts (e.g., reducing papules, pustules, or cysts)

(2014) 220:R5765

Sep-Oct 2013;16(5):E563-575

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ROS inhibits STING dimerization by oxidizing Cysteine 147 on murine STING during MHV68 infection