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This submission initiates a review process that typically spans 10 to 12 months, positioning potential FDA approval for late 2027 or early 2028, with commercial access likely following in the first half of 2028

doi: 10.1016/j.cmet.2021.12.001

ABSTRACT KEY FIGURE Highlights INTRODUCTION DISCOVERY OF GLP-1 AND DEVELOPMENT OF INCRETIN-BASED DRUGS GLP-1 AND IMPLICATIONS IN COGNITIVE SATIATION: HUMAN STUDIES HYPOTHALAMIC FUNCTIONS IN COGNITIVE FEED-FORWARD REGULATION HYPOTHALAMIC CONTROL OF GLP-1 ACTIONS ON SATIATION AND SATIETY: ANIMAL STUDIES ONGOING FUTURE STUDIES OF GLP-1R AGONISTS NOTES REFERENCES About this article ABSTRACT Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as blockbuster drugs for treating metabolic diseases

GSH is oxidized to GSSG or decomposed to amino acids in blood, and the Cys in blood is easily oxidized to cystine