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Azathioprine is a masked form of 6-mercaptopurine, since it is composed of 6-mercaptopurin linked via a thioether bond with an imidazole ring [125]

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Increased oxidative stress not only damages melanocytes, but also induces autoimmunity through the upregulation of the calreticulin expression and translocation to the cell membrane17

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The consistency of metabolites between positive and negative experiments were also checked (retention time, CCS values, and fold changes)

This keeps all titration and maintenance doses within the range of a standard 100-unit insulin syringe