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The above article does mention its use for the treatment of glaucoma

MtDNA Methylation Levels Analysis at MTCO1 and the D-Loop Region As no changes for TMAO were observed in the control (i.e., 24 weeks resistance training without any supplementation) and l-leucine group, mtDNA methylation levels were primarily assessed in the control ( n = 8) and l-leucine + l-carnitine group ( n = 9), both before and after the intervention

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In addition, the cycle can produce NADPH in addition to NADH, due to the activity of isozymes that reside either in the mitochondria (isocitrate dehydrogenase 2/IDH2) or cytosol (IDH1 or malic enzyme/ME1) (Rydstrom, 2006)

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