Advantages: Localized delivery to target tissue (skin, scalp) Non-invasive Lower systemic exposure Well-tolerated with established safety record in cosmeceuticals Limitations: Limited dermal penetration (molecular weight ~340 Da near the cutoff for transdermal absorption) No systemic anti-aging or anti-inflammatory effects Efficacy dependent on formulation vehicle (liposomal carriers significantly improve penetration) GHK-Cu Injection (Subcutaneous) GHK-Cu injection is explored in research settings for systemic administration
The 2-4 hour plasma half-life might initially suggest benefit from divided doses, but the relevant biological effects persist far beyond plasma clearance
In one study, obese Zucker rats received daily oral doses of AOD 9604 for 19 days
PRECAUTIONS FOR USE: This product does not interfere with any other medication and does not have any kind of contraindication
436 Besides, the MT1 gene cluster has been found to be hypermethylated in EBVaGC, suggesting redundant anti-EBV roles among various MT1 genes
Geisen C, Watzka M, Sittinger K, Steffens M, Daugela L, Seifried E et al
