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Owing to intracellular GSH concentrations above 2 mM depletion of GSH as such has little metabolic consequences unless an additional stress is superimposed

AOPPs, advanced oxidation protein products

Microbial therapeutics Microbiota-targeted therapeutic strategies can be organized into a pragmatic taxonomy spanning (i) dietary modulation (addressed in Sect

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Specifically, increased reactive oxygen species is known to activate the AMPK, p38 mitogen-activated protein kinase, and nuclear factor-B pathways, each of which plays a role in antioxidant production pathways (Irrcher et al., 2009