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If exposure has occurred, you need to assess the degree of damage based on temperature reached and duration, not simply refrigerate and hope for the best

Bicarbonate may improve buffering when metabolic acidosis or low bicarbonate is present

Epidemiology 33(4):563571 Nauck MA, Jensen TJ, Rosenkilde C, Calanna S, Buse JB, Investigators LPCobotLT

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

While generally safe, it is important to be aware of potential drug interactions

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