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Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element

doi: 10.1152/ajpregu.00588.2012

1 GLP-1 receptor agonists have been shown to exert varying beneficial effects, including anti-inflammatory, neurotrophic, and neuroprotective actions

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doi: 10.1385/ENDO:14:1:101 51 LiuH.SunD.MyasnikovA.DamianM.BaneresJ

Conditions primarily driven by autoantibody-mediated mechanisms, like lupus or myasthenia gravis, are less likely to see meaningful benefit from tirzepatide anti-inflammatory properties