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The body has fully adapted to that concentration, and adding more will produce a predictable increase rather than an unpredictable spike

Fatty infiltration of the pancreas promotes impaired pancreatic -cell function and gradual hyperglycemia, which will further enhance de novo hepatic lipogenesis and promote higher NEFAs levels to the circulation (the twin cycle hypothesis) [18]

5ag), but not in DIO mice that lack the GLP-1 receptor (Fig

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