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Preclinical research shows that some of these receptors are found in the area postrema , a part of the brainstem often called the vomiting center. When you take semaglutide or tirzepatide, this center lights up, signaling to your body that its time to feel nauseous

Chang et al., 2024)

The data revealed that the members on microdoses encountered destabilizing side effects

Factors such as starting dose, rate of dose escalation, concurrent medications, and underlying health conditions all influence tolerability

doi:10.1056/NEJMoa2301972 (4) Sigma-Aldrich

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