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Summary Keywords allergic asthma, immunometabolism, innate immunity, innate lymphoid Cells (ILC2), pentose phosphate pathway, redox homeostasis and signaling, respiratory immunology Citation Cain J, Hurrell BP, Shen S, Speliakos P and Akbari O (2026) Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming