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They provide the most benefit when combined with a healthy diet and regular physical activity

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Although many of these changes are nonspecific, they can give a diagnostician reason to suspect the presence of a systemic disease

Symptoms of dyspepsia, nausea, vomiting, bloating, diarrhea, and constipation stand out among the gastrointestinal adverse effects described.514 The presence of gastrointestinal adverse effects associated with antidiabetics has an overall impact on the patient with diabetes, given that they can increase the need for medical attention, affect quality of life due to the symptoms they trigger, and modify therapeutic regimens

Weight loss and muscle loss often go hand-in-hand

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