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The ESSENCE trial (NCT04822181) enrolled 1,197 adults with biopsy-proven MASH and moderate to advanced liver fibrosis (Stage F2 to F3)

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1 Consider treatment response and tolerability when selecting the maintenance dosage 1 Recommended maintenance doses: Adult CV risk reduction: 1.7 mg or 2.4 mg (recommended) Adult weight reduction: 1.7 mg, 2.4 mg (recommended), or 7.2 mg (when additional weight reduction is clinically indicated) Adolescent weight reduction: 1.7 mg or 2.4 mg (recommended) CV, cardiovascular

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Semaglutide works optimally in patients with insulin resistance, dysglycemia, or weight-related comorbidities