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Sera from HFD-fed recipients showed lower Met to Hcy ratio and higher 3-nitrotyrosine levels than sera from CD-fed recipients (Figures 4AD)

The production of large amounts of NO by activation of iNOS expression in macrophages represents the major cytotoxic activity of these cells

Chronic inflammation, in turn, exacerbates aging of the immune niche 8

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10.1056/NEJM199806253382603 N Engl J Med

In particular, the oxidation state of two out of six cysteines controls the CAC via the formation of a disulfide bridge that switches off the transporter activity