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Author contributions AS conducted bioinformatic analyses related to biomarker, clustering, and association analyses

Treatment-related effects were mild or moderate

What makes this evidence particularly relevant is that most participants in these trials were already taking metformin when they started tirzepatide

The weight loss effect is most pronounced during the first 6 months of treatment as your body adjusts to the medication and dosing reaches therapeutic levels

The medication works through a dual mechanism of action that targets two incretin hormone pathways simultaneously

This post shares what is known and what to maybe ask your doctor