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Iron stores may become depleted before hemoglobin falls, and neurological symptoms associated with vitamin B12 deficiency can occur without anemia

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[46] [48] Pathophysiology [edit] Although the healthy body stores three to five years' worth of B 12 in the liver, the usually undetected autoimmune activity in one's gut over a prolonged period of time leads to B 12 depletion and the resulting anemia

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B12: Neurological Function & Mental Clarity Essential for myelin sheath synthesis the protective coating around nerve fibers