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First you will see a report from 1971 that in a study on excessive prescribing, B12 treatment was singled out, possibly due to the idea that GPs were giving patients B12 injections, willy nilly as a tonic

This was done by employing an engineered cyst(e)inase enzyme resulting in the suppression of tumor growth in breast and prostate cancer xenografts (53)

(PubMed) Smith AD, Refsum H