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Instead, its research-relevant effects appear to involve modulation of several signalling pathways most prominently angiogenesis via the VEGF pathway, gastric and gut-lining protective signalling, and to a lesser extent growth factor modulation and nitric oxide system interaction

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Some studies have measured the whole bone marrow fluid selenium level and found that the selenium level is reduced, and hair selenium level in children with leukemia decreased significantly ( Ferrum and ALL The mechanisms related to cancer may be that ferrum is needed as a cofactor for cell proliferation and growth, and research revealed that ferrum deficiency reduces the aggressiveness of tumor cells ( Other trace elements Although the molecular mechanism is still unclear, Nickel is still considered a carcinogenic trace element ( 131 I) is known to cause chromosome aberration, there is no large-scale epidemiological data to prove that the incidence rate of ALL has significantly increased, except for a few sporadic reports of cases leading to ALL, it is necessary to monitor patients hematological indicators after 131 I treatment ( Trace elements affect DNA synthesis and participate in regulating ALL The characteristics of ALL may be related to the gene changes of differentiation and proliferation of lymphoid precursor cells ( Furthermore, some metal ions play a role in maintaining genomic stability

Wolraich et al., 2019)