Providing access to compounded GLP-1s means eligible customers can use medications with the same active ingredient as Ozempic and Wegovy without navigating the shortages and costs that are currently limiting access to the branded medications
Abbreviations Akt: Protein kinase B BMI: Body mass index cAMP: Cyclic adenosine monophosphate CGRP: Calcitonin gene-related peptide DM: Diabetes mellitus DPP: 4-dipeptidyl peptidase-4 GLP: 1-glucagon-like peptide-1 GLP: 1R-glucagon-like peptide-1 receptor HbA1c: Glycated hemoglobin IGF: Insulin-like growth factor MAPK: Mitogen-activated protein kinase mTOR: Mammalian target of rapamycin NF: B-nuclear factor B PI3K: Phosphoinositide 3-kinase PKA: cAMP-dependent protein kinase SGLT: 2-sodium-glucosecotransporter-2 T2DM: Type 2 diabetes mellitus References Iijima, T., Shibuya, M., Ito, Y., & Terauchi, Y
August 2024: A data analysis examining how semaglutide drugs in the GLP-1 agonist family might cause blood clots is being re-examined
Mechanisms Mediating the Diuretic and Natriuretic Actions of the Incretin Hormone Glucagon-Like Peptide-1
Step 2: Gather and inspect supplies Set out your vial, a new insulin syringe, an alcohol swab, gauze or cotton ball, and your sharps container
Rosen CJ, Ingelfinger JR