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MetS is less prevalent in South and Southeast Asia

Sub-optimal action of the complex regulatory mechanisms governing the interplay between BH4 oxidation and glutathionylation of eNOS cysteine residues may also induce eNOS uncoupling, highlighting the complex regulatory mechanisms involved in this process [74]

10.1016/j.chemosphere.2017.11.124 93 MayhewA

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In PCOS, the pathogenesis of ferroptosis involves not only Hepc downregulation and subsequent increases in intestinal iron absorption but also the influence of gut microbiota and their metabolites