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The ECHO-301/KEYNOTE-252 trial showed that combining epacadostat with pembrolizumab failed to prolong progression-free survival (PFS) or overall survival (OS) compared to pembrolizumab alone in patients with advanced melanoma

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Alongside weight loss, the trial showed improvements in physical function and across a spread of cardiometabolic risk factors: waist circumference, HbA1c, fasting glucose, lipid profile, blood pressure, and C-reactive protein (Wharton et al., 2025)

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