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Each has its own evidence base and safety boundary
Henry et al
Eckert DJ, Younes MK
Many of the medications and injections marketed to alleviate joint-related pain also have many negative side effects, even causing the joint to deteriorate over time
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Begin with the manufacturer's recommended dose Adjust dose depending on therapeutic response and side effects Regular follow-up consultations to ensure optimal dosing For oral administration: Initially 3 mg once a day for 30 days Then increase to 7mg once daily for 30 days Then 14 mg once a day target dosage if warranted Swallow whole on an empty stomach, at least 30 minutes before eating No dosage adjustment in hepatic or renal impairment Adjusting Dosages Based on Health Goals Dosage adjustments for both medications should be tailored to individual health goals and outcomes
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