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Differences between two groups were evaluated using t -test

Despite these caveats, an increase in brain lactate in ME/CFS patients has been previously reported in 3T MRS investigations, in the ventricle CSF rather than in the brain tissue [14,15,16,17], and also in the ACC, similar to our study (the voxel in this study was placed in the area covering adjacent parts of our voxels) [13]

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