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In young children this might lead to cumulative effects although the extent of accumulation of adverse effects is not known ( The utility of octreotide and other SST2 agonists are often complicated by loss of effect with increasing dose in the initial phase of treatment

Kick A, et al (2024) Real-world use of oral semaglutide in adults with type 2 diabetes: the PIONEER REAL Switzerland multicentre, prospective, observational study

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Opioid receptors are found in both the CNS and the periphery