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The trial's justification is based on the discovery that CD20 is expressed by melanoma cancer cells and that killing CD20+ cells in preclinical models produces potent anticancer effects [229]

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Options may include SGLT2 inhibitors, metformin, thiazolidinediones, or insulin for diabetes, noting that DPP-4 inhibitors also carry pancreatitis warnings

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At Rivas Medical, for example, when we first started using semaglutide we found patients reported more side effects when they jumped from 0.5mg to 1.0mg per week