While its primary use is in managing seizures and migraines, topiramate also affects pathways in the brain that influence appetite and how things taste
10.1016/j.jece.2022.108699 [DOI] [Google Scholar] Xiao, J.H
Oncogenic RIT1 mutations not only activate canonical RAS/MAPK and PI3K/AKT pathways but also modulate nuclear factor, erythroid 2 like 2 (NRF2) target expression, markedly increasing cellular susceptibility to ferroptosis inducers (33)
Individual response varies based on genetics, metabolism, and appetite-driving factors
Critically, this disparity persists under comparable nutritional support regimens, with plasma free carnitine concentrations remaining significantly lower in RDS infants from day 3 to day 7 postpartum (69)
There have been no trials so far either