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Pathophysiologically, seizures primarily result from abnormal activity in cortical neurons

Understanding bioavailability explains why injectable doses are measured in milligrams while topical concentrations use percentages

Nervous System Effects: Lightheadedness, dizziness, euphoria, drowsiness, or, rarely, seizures

This leads to decreased insulin production through the translocation of the transcription factor pancreatic and duodenal homeobox 1 (Pdx1) from the nucleus to the cytoplasm, resulting in decreased Insulin transcription (56) ( Figure 2K )