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And in June 2026, the first dedicated diabetes Phase 3 trial (TRANSCEND-T2D-1) confirmed 16.8% weight loss alongside -2.0% HbA1c reduction in 537 type 2 diabetes patients

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Paunel Vukasinov, M.D., an internal medicine doctor at Medical Offices of Manhattan in New York

These results suggest that increased plasma serotonin may contribute to regulation of postprandial glucose metabolism, potentially via effects to increase both GLP-1 and insulin secretion