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In addition to the inherent challenges associated with these agents, Gln metabolism lacks tumor specificity and involves multiple metabolic pathways within cells, which can lead to false positives in areas of high metabolic activity

[28] After inducing the stroke through acute occlusion of the middle cerebral artery, the rats were given 30mg/kg NSI-189 orally, beginning 6 hours after the stroke induction and continuing daily for 12 weeks

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