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In one study, FI-SARS-CoV reduced viraemia and protected against lung pathology in rhesus macaques 124 , whereas in another study macaques given FI-SARS-CoV developed macrophage and lymphocytic infiltrates and alveolar oedema with fibrin deposition after challenge, indicating the difficulties of establishing consistent NHP models 125
The data indicate that altering the anatomical route and kinetics of nutrient presentation to the distal gut reinstates physiological lipid fluxes and mitigates metabolic dysregulation (7, 49)
