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Where the 25% benchmark comes from The benchmark that ~25% of weight lost is FFM under caloric restriction comes from decades of work on diet-induced weight loss

Wegovy pill is only approved in the US and will be available in 1.5 mg (starter dose), 4 mg, 9 mg, and 25 mg

Nutritional deficiencies may develop during rapid weight loss if dietary intake becomes inadequate or poorly balanced

However, rapid or significant weight changes can occasionally trigger mood episodes in susceptible individuals

GLP-1 also slows down the passing of food through the stomach, which can lead to the sensation of fullness that lasts for a longer period of time

The method for developing the summary of findings (SoF) table and determining the quality of evidence as high, moderate, low, or very low has been described elsewhere [19]