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Interestingly, adjusting for the decrease in HbA1C in the treatment group attenuated the renal effects of dulaglutide by about 26%, suggesting that the efficacy of GLP1RA is independent of their ability to alter this major CKD risk factor [71]

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The DNA-binding domain contains two zinc-binding motifs necessary for dimerization and DNA binding, while the hinge region contains two nuclear localization signals needed for transport through the nuclear pore (20, 21)