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These mechanisms not only aid in reducing body mass but also enhance glycemic control, making tirzepatide especially advantageous for individuals with obesity and type 2 diabetes

Both trials were prospectively registered (NCT02465515 and NCT01144338)

And anyone with severe renal impairment should discuss both compounds with their physician before proceeding

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Itaconate (ITA) is an endogenous metabolite from the tricarboxylic acid cycle, which has been confirmed to suppress osteoarthritis by reducing the activation of STING-dependent NF-B pathway