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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation

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This method operates at moderate temperatures, which helps preserve the structural integrity and bioactivity of heat-sensitive polyphenols ( However, supercritical fluid extraction also has limitations

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If a patient is found to be allergic to a particular drug group, pharmacogenetic screening can be considered