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The major types of gastrointestinal (GI) cancers include colorectal cancer, gastric cancer, esophageal cancer, liver cancer, and pancreatic cancer, each with distinct risk factors, clinical presentations, and treatment challenges

doi:10.1172/jci.insight.90777 87

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Other irAE research has focused on the role of human leucocyte antigen (HLA) genes, a complex of genes involved in regulating immune responses, that may be implicated in the development of particular autoimmune diseases, such as atopic dermatitis and IBD

SAG uses a thioester (S-acyl) bond, which is cleaved specifically by cytoplasmic thioesterases, offering a more targeted intracellular release mechanism with a cleaner safety profile demonstrated in human dosing studies

Anti-inflammatory and gut microbiota modulatory effect of lactobacillus rhamnosus strain ldtm 7511 in a dextran sulfate sodium-induced colitis murine model