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administration of the experimental compounds (MK-801, GLP-1, GLP-1MK-801 (all at doses of 100 nmol kg 1 ), semaglutide (10 nmol kg 1 ) or isotonic saline as vehicle)

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Cells expressing the SCoV M pro also became apoptotic, which is a known consequence of NF-B activation, especially in combination with a high burden of ROS (19), which is even more likely to occur if other antioxidant proteins are also degraded, as discussed below

The reoxidation of compounds with iodine containing molecules in the presence of O 2 through hydrogen peroxide (H 2 O 2 ) intermediates has been previously demonstrated 37

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