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Moreover, metformin has been demonstrated to prevent venous and arterial thrombosis by inhibiting platelet activation and extracellular mitochondrial DNA release in carotid and vena cava animal models (Xin et al., 2016)

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Some early trials from the 1990s claimed peptides were free of side effects but were never published in peer-reviewed journals, only mentioned in abstracts by the peptides original proponents

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