What side effects of GLP-1s should be considered
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In perimenopausal or postmenopausal women, early data support efficacy regardless of reproductive stage , although research focused specifically on perimenopause remains limited
These findings support further evaluation in the ongoing phase 3 programme
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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state