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A lower starting dose or careful monitoring may be indicated based on individual tolerance and response

10.1016/j.cell.2017.09.046 309 XiangY.StineZ

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[DOI] [PubMed] [Google Scholar] 72.Ungvari Z, Sonntag WE, de Cabo R, Baur JA, Csiszar A

If Phase III data support approval, and early signals for both are positive, TGA registration applications could follow