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Common side effects include gastrointestinal issues such as nausea and vomiting, a possible increased risk of pancreatitis, low blood sugar levels especially when combined with other medications, and reactions at the injection site

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J Clin Pharmacol (2015) 55:1528

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This reduced caloric intake semaglutide creates a calorie deficit, which can cause you to experience fatigue or feel tired as your body adapts