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But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

(Mildly exfoliating the skin beforehand can help mimic the initial abrasive stages of skin repair to enhance the effectiveness of GHK-Cu) Wash your face with a mild cleanser (neutral or slightly acidic pH)

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Smoothies made with yoghurt, berries and a scoop of protein powder can be easier to manage on days when eating feels difficult